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The idea that viral infections may lead to chronic disease, especially of the nervous system, had been entertained since the 1920s, but only in relatively recent years was it rmly established The following indirect and direct evidence supported this view: (1) the demonstration of a slowly progressive nonin ammatory degeneration of nigral neurons long after an attack of encephalitis lethargica; (2) the nding of inclusion bodies in cases of subacute and chronic sclerosing encephalitis; (3) the discovery of chronic neurologic disease in sheep caused by a conventional RNA virus (visna) it was in relation to this disease in sheep that Sigurdsson rst used the term slow infection to describe the long incubation periods during which the animals appeared well; and (4) the demonstration by electron microscopy of viral particles in the lesions of multifocal leukoencephalopathy and, later, isolation of the virus from the lesions The suggestion that the late onset of progressive weakness after poliomyelitis ( postpolio syndrome ) might represent a slow infection has never been veri ed Claims have also been made by numerous groups for a viral causation of multiple sclerosis, amyotrophic lateral sclerosis, and other degenerative diseases, but the evidence is questionable The slow infections of the nervous system due to conventional viruses include subacute sclerosing panencephalitis (measles), progressive rubella panencephalitis, progressive multifocal leukoencephalopathy (JC virus), and visna in sheep These slowly progressive diseases, except for progressive multifocal leukoencephalopathy (PML), are decidedly rare They are caused by conventional viruses and are not to be confused with a group of chronic neurologic diseases that also are sometimes referred to as slow infections but are due instead to nonconventional transmissible agents, now called prions These are accorded a separate section later in this chapter Subacute Sclerosing Panencephalitis (SSPE) This disease was rst described by Dawson in 1934 under the title inclusion body encephalitis and extensively studied by Van Bogaert, who renamed it subacute sclerosing panencephalitis It is now recognized to be the result of chronic measles infection Never a common disease, the condition occurred until recently at a rate of about one case per million children per year With the introduction and widespread use of measles vaccine, it has practically disappeared in the United States Along with the eradication of polio, this has been one of the important advances in preventative neuropediatrics Subacute sclerosing panencephalitis affects children and adolescents for the most part, rarely appearing beyond the age of 10 years Typically there is a history of primary measles infection at a very early age, often before 2 years, followed by a 6- to 8-year asymptomatic period The illness evolves in several stages Initially there is a decline in pro ciency at school, temper outbursts and other changes in personality, dif culty with language, and loss of interest in usual activities These soon give way to a severe and progressive intellectual deterioration in association with focal or.

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How to generate a barcode in Excel | Sage Intelligence
Aug 10, 2017 · Applies To: Microsoft® Excel® for Windows 2010, 2013, and 2016. Excel has no built-in functionality to generate a barcode. However, this is ...

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430 The field-effect transistor 5 In a P-channel JFET: A The drain is forward-biased B The gate-source junction is forward biased C The drain is negative relative to the source D The gate must be at dc ground 6 A JFET is sometimes biased at or beyond pinchoff in: A A power amplifier B A rectifier C An oscillator D A weak-signal amplifier 7 The gate of a JFET has: A Forward bias B High impedance C Low reverse resistance D Low avalanche voltage

Figure 33-3 MRI of the cervical cord MRI in a patient with nonpoliovirus poliomyelitis and an asymmetrical, accid, bibrachial paralysis There is T2 signal change in the anterior regions of the gray matter

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Barcode Add-In for Microsoft Excel (All Versions) - YouTube
Jun 10, 2010 · http://tec-it.com - This tutorial video shows you how to print barcodes with Excel 2007, Excel ...Duration: 2:52 Posted: Jun 10, 2010

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How to insert a barcode object in Word and Excel (Office XP and 2003)
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generalized seizures, widespread myoclonus, ataxia, and sometimes visual disturbances due to progressive chorioretinitis As the disease advances, rigidity, hyperactive re exes, Babinski signs, progressive unresponsiveness, and signs of autonomic dysfunction appear In the nal stage the child lies insensate, virtually decorticated The course is usually steadily progressive, death occurring within 1 to 3 years In about 10 percent of cases the course is more prolonged, with one or more remissions In a similar number the course is fulminant, leading to death within months of onset Exceptionally, the disease occurs in young adults In two reported cases in pregnant women, blurred vision and weakness of limbs developed before they became akinetic and mute, without a trace of myoclonus or cerebellar ataxia Nevertheless, the progressive ataxic-myoclonic chronic dementia in a child is so typical that bedside diagnosis is usually possible The EEG shows a characteristic abnormality consisting of periodic (every 5 to 8 s) bursts of 2- to 3-per-second high-voltage waves, followed by a relatively at pattern The CSF contains few or no cells, but the protein is increased, particularly the gamma globulin fraction, and agarose gel electrophoresis discloses oligoclonal bands of IgG These have been shown to represent measles virus speci c antibody (Mehta et al) Both the serum and CSF contain high concentrations of neutralizing antibody to measles (rubeola) virus, but the virus has been recovered from the brain tissue only with dif culty The MRI changes begin in the subcortical white matter and spread to the periventricular region (Anlar et al) Histologically the lesions involve the cerebral cortex and white matter of both hemispheres and the brainstem The cerebellum is usually spared Destruction of nerve cells, neuronophagia, and perivenous cuf ng by lymphocytes and mononuclear cells indicate the viral nature of the infection In the white matter there is degeneration of medullated bers (myelin and axis cylinders), accompanied by perivascular cuf ng with mononuclear cells and brous gliosis (hence the term sclerosing encephalitis) Eosinophilic inclusions, the histopathologic hallmark of the disease, are found in the cytoplasm and nuclei of neurons and glial cells Virions, thought to be measles nucleocapsids, have been observed in the inclusion-bearing cells examined electron microscopically How a ubiquitous and transient viral infection in a seemingly normal young child allows the development, many years later, of a rare encephalitis is a matter of speculation Sever believes that there is a delay in the development of immune responses during the initial infection and a later inadequate immune responses that are incapable of clearing the suppressed infection An alternative hypothesis is that certain brain cells fail to synthesize a so-called M protein, which is essential for the assembly of the viral membrane, and that this limitation of host-cell capability is related to the extent of viral seeding of the brain during the initial infection (Hall et al) The differential diagnosis includes the childhood and adolescent dementing diseases such as lipid storage diseases (Chap 37) and Schilder demyelinative disease (page 782) In presumptive clinical cases of SSPE, the ndings of periodic complexes in the EEG, elevated gamma globulin and oligoclonal bands in the CSF, and elevated measles antibody titers in the serum and CSF are suf cient to make the diagnosis No effective treatment is available The administration of amantadine and inosiplex was found by some investigators to lead to improvement and prolonged survival but others could not corroborate these effects The therapeutic value of intrathecal administration of alpha interferon is being investigated.

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Using the Barcode Font in Microsoft Excel (Spreadsheet)
Tutorial in using the Barcode Fonts in Microsoft Excel 2007, 2010, 2013 or 2016. All the functions ... It is extremely easy to create and print barcodes in Excel.

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Barcode Add-In for Microsoft Excel (All Versions) - YouTube
Jun 10, 2010 · http://tec-it.com - This tutorial video shows you how to print barcodes with Excel 2007, Excel ...Duration: 2:52 Posted: Jun 10, 2010

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